Berberine vs Dihydroberberine a cikin Rage Nauyi

Berberine an san shi da tasirinsa kamar magance gudawa da kuma rage yawan sukari a jini, amma me yasa ake cewa yana da kaddarorin hana tsufa? Mun san cewa sarrafa metabolism da kuma sarrafa circadian rhythm (wanda yawanci abu ɗaya ne, misali, cin abincinka kafin ƙarfe 3 na yamma yana inganta alamun lafiya daban-daban, wanda shine sarrafa metabolism da kuma sarrafa circadian rhythm) sune mafi mahimmancin hanyoyin magance tsufa, na biyu kawai bayan daina shan taba da iyakance shan barasa da motsa jiki akai-akai.

Berberine yana da sauƙin canza yanayin sarrafa metabolism. Ka tuna yadda acarbose ke sarrafa sukarin jini jiya? Ta hanyar rage shan ruwa, ko ba haka ba? Berberine A cewar "Tasirin Berberine akan Blog Glucose, Glycated Hemoglobin A1, Serum Insulin, C–Peptide, Juriyar Insulin da kuma β– Cell Physiology", berberine zai iya haɓaka ɗaukar glucose da amfani da ƙwayoyin tsoka da hanta ta hanyar ampk, yayin da yake hana gluconeogenesis na hanta, ta haka ne rage matakan sukari na jini yadda ya kamata. A lokaci guda, ampk da kansa shi ma babban abin da ake buƙata don hana tsufa ne.

A cewar wannan takarda: "Berberine da kuma Metformin a cikin Maganin Ciwon Suga Nau'i na 2: A cikin "Bita na Tsari da Nazarin Meta-Nazarin Gwaje-gwajen Asibiti na Randomized", haɗin metformin da berberine ga marasa lafiya da ke fama da ciwon suga na nau'in 2 yana da tasirin haɗin gwiwa.

Bugu da ƙari, berberine, kamar acarbose, yana da aikin ciyar da hanji. Saboda ƙarancin samuwarsa bayan shan ta baki, yana taruwa sosai a cikin hanji, yana daidaita tsari da aikin ƙwayoyin cuta na hanji da kuma ƙara yawan ƙwayoyin cuta waɗanda ke samar da fatty acids na gajerun sarƙoƙi (kamar butyrate). Don ƙarin bayani, da fatan za a duba labarin "Pharmacology of Berberine da kuma Metabolites ɗinsa, shin yanayi ne na Ozempic ko Imatinib?" wanda ke tattauna yadda berberine ke aiki da kuma hanyoyin da za a iya bi.

Sannan zai iya yin duk abin da masu maganin AMPK za su iya yi, kamar rage kitsen jini ta hanyar kunna AMPK don hana haɗakar fatty acids da cholesterol. Hakanan zai iya yaƙi da juriyar insulin ta hanyar rage damuwa ta endoplasmic reticulum da hana abubuwan kumburi (kamar TNF-α) da inganta yanayin masu karɓar insulin.

Ba shakka, akwai kuma aikinta na maganin kashe ƙwayoyin cuta mai faɗi, wanda aka yi amfani da shi tsawon shekaru marasa adadi ta hanyar lalata amincin bangon ƙwayoyin cuta da membranes, hana haɗakar furotin da DNA, da kuma tsoma baki ga metabolism na ƙwayoyin cuta (saboda haka ana amfani da shi akai-akai wajen magance dysentery da bacterial gastroenteritis a lokutan ƙarancin abinci). Wannan ɓangaren ba ya ƙarƙashin rukunin hana tsufa, don haka ba zan yi bayani dalla-dalla ba. Hakazalika, ba zan yi cikakken bayani game da nazarin tsawaita tsawon rai a cikin samfuran ƙudaje da tsufa na beraye ba, saboda kodayake sakamakon yana da kyau, ba nazarin ɗan adam ba ne. Don yin taka tsantsan, a cikin nazarin ɗan adam, za mu iya tattauna takamaiman tasirin kawai.

Na san kana sha'awar gwadawa, na san ba ka da haƙuri, amma kada ka yi gaggawa.

A cewar binciken "Ingancin Berberine A cikin Marasa Lafiya da ke fama da Ciwon Suga Nau'i na 2" a cikin marasa lafiya da ke fama da ciwon suga na tsawon makonni 13, kashi 34.5% na marasa lafiya sun fuskanci mummunan sakamako a cikin hanji bayan sun sha berberine. Wannan ya faru ne saboda yawan maganin hana tsufa da ciwon suga ya fi yadda aka saba amfani da shi wajen maganin rigakafi. Bugu da ƙari, saboda bambancin ƙwayoyin cuta a cikin hanji, wasu mutane sun fuskanci mummunan gudawa yayin da wasu kuma suka sha matsanancin maƙarƙashiya. Dalilin da ya sa ban sha berberine ba shine saboda ni ma ina fama da maƙarƙashiya. Yin fitsari kamar jan wuka, kuma wa ya fahimci jin rashin iya yin bahaya ko da da wuka?

Ba zan ambaci illar da ke ƙasa da kashi 0.1% ba, domin suna da yawa, amma gudawa/maƙarƙashiya tana da matuƙar tsanani, kuma yawanta ya yi yawa. Idan da gaske kana son shan ta, dole ne ka daina shan ta nan take idan ka ga ba ka jure ta ba, domin wannan abu yana aiki akan ƙwayoyin cuta na hanji, ba kamar magungunan neurotransmitter da za ka iya jurewa ba kuma ka daina samun matsala da su akan lokaci. Za ka iya samun gudawa wata rana sannan ka maƙarƙashiya a gaba.

Idan kana da sa'a ka kasance mai jituwa da berberineBarka da warhaka, amma za ku fuskanci wasu matsaloli. Misali, berberine a zahiri yana zuwa a cikin nau'ikan magani da yawa azaman kari a kasuwar Amurka da Turai. Bayan haka, berberine hydrochloride, akwai wani sinadari da aka fara amfani da shi a hankali a cikin wasu ƙarin dabarar dihydroberberine.

Menene bambanci? Da farko, samuwar dihydroberberine a zahiri ya fi na berberine hydrochloride (misali, yawan shan sa a cikin vitro ya ninka na berberine sau 11.9, kuma ƙimar AUC ɗin sa a cikin plasma a gwaje-gwajen dabbobi ya ninka na berberine sau 4.8). A daidai wannan adadin, akwai bincike (wanda aka tabbatar da cewa an tallafa masa ta hanyar alama, don haka ba a lissafa takaddun ba) waɗanda suka kammala da cewa dihydroberberine yana da ingantaccen tasirin hana tsufa a gwaje-gwajen dabbobi.

Duk da haka, ingancin farashi har yanzu yana da ƙasa sosai. Bayan haka, ci gaba sau 4.8 na iya dacewa da farashin ninki 48 ko ma mafi girma... Matsalar ita ce lithium carbonate ba zai iya maye gurbin lithium orotate ba saboda lithium orotate yana da ƙarfin ikon ketare shingen jini-kwakwalwa, wanda ke canza halayensa kai tsaye, kamar magnesium threonate idan aka kwatanta da sauran magnesium.

Berberine ya fi kusa da coenzyme Q10Muddin ba sifili ba ne, za a iya magance shi ta hanyar ninka adadin. Saboda haka, ruwan da ke narkewa a jiki har ma da foda coenzyme Q10 (Ubiquinone) ba a taɓa kawar da shi ta hanyar rage nau'in Ubiquinol (Kaneka daga Japan) tare da yawan samuwa a cikin jiki ba.

Daga wannan mahangar, tabbas lamari ne na "biya harajin IQ." Duk da haka, har yanzu za mu iya gani daga binciken da aka yi na makonni 13 na samfurin ciwon suga cewa mafi girman adadin da aka ɗauka, mafi girman yuwuwar samun illa. Bugu da ƙari, berberine hydrochloride yana buƙatar a canza shi zuwa dihydroberberine ta hanyar ƙwayoyin cuta na hanji don sha, kuma a ƙa'ida, dihydroberberine hakika muhimmin abu ne. Yana da kyau a yi hasashe cewa ga mutanen da ba sa jure wa berberine hydrochloride, canzawa zuwa dihydroberberine na iya rage yiwuwar samun illa, don haka ya sa ya fi jurewa.

Duk da haka, kamar yadda tsohuwar magana ta ce, tun da tsarin aikin berberine Yana iya zama kamar ya yi karo da ƙuntatawar kalori (manufar AMPK), idan madadin bai yi nasara ba, me zai hana kawai rage adadin kuzari kai tsaye? Babu wani dalili na kashe kuɗi ba tare da wani dalili ba. Fahimtata game da shi ta karkata zuwa ga gyara; idan kun tabbata za ku ci abinci fiye da kima a lokacin hutu, za ku iya ɗaukar shi a gaba a matsayin matakin rigakafi. Amma a ranakun yau da kullun, ya fi kyau kawai a takaita adadin kuzari kai tsaye.

Har ila yau, idan kun iya yin magana berberine, to shan wani nau'in da ke da ƙarancin samuwa zai fi taimakawa wajen haɓaka ƙwayoyin cuta na hanji. Shi ya sa ban lissafa nazarin da aka yi wa kamfani ba; sun yi amfani da magani iri ɗaya kuma sun mai da hankali sosai kan tasirin hana glycation da rage kitse maimakon halayensa na haɓaka ƙwayoyin cuta na hanji. Siyan kayayyaki na iya zama ɓarna, kuma karanta takardu na ilimi ba ya bambanta.

A ƙarshe, idan har yanzu kuna sha'awar berberine Bayan karanta wannan zuwa yanzu, ga wasu nasihu: Berberine kuma chromium suna da tasirin haɗin gwiwa (berberine yana inganta juriyar insulin ta hanyar amfani da tsarin AMPK (maganin hana kumburi) da kuma daidaita ƙwayoyin cuta na hanji ta hanyar da ba ta dogara da insulin ba, yayin da chromium ke ƙara haɓaka siginar insulin kai tsaye a matakin masu karɓar ƙwayoyin halitta. Haƙiƙa haɗuwa ce ta tasirin macroscopic da ƙananan ƙwayoyin cuta, a ka'ida yana haifar da tasirin "1+1>2". Saboda haka, ya dace ga kamfanoni da yawa su ƙara chromium a cikin su. berberine kayayyakin.