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2025-08-26

Labaran Quercetin 6 - pic1.jpg

Masu bincike daga Jami'ar Zhejiang sun gano wani tsari mai inganci na siginar hanji da hanta wanda ke amfani da shi ta hanyar da ta dace quercetin, wani sinadari mai suna flavonoid, yana yaƙi da kiba. An buga a cikin Kimiyya Mai Ci Gaba (Janairu 31, 2025), binciken ya gano Akkermansia muciniphilakwayoyin cuta da kuma bile acid Metabolism a matsayin masu shiga tsakani masu mahimmanci naquercetinyana rage lipids, yana ƙara yawan aikinLahadipeutic yana nufin matsalolin metabolism.

Bayanin Bincike

Kiba da cututtukan da suka shafi metabolism suna haifar da ƙalubalen kiwon lafiya a duniya, suna haifar da sha'awar shiga cikin ayyukan halitta kamar quercetinDuk da ingancinsa da aka sani, madaidaicin hanyar da ke haɗa Quercetin Har yanzu ba a gano yadda ake sake fasalin ƙwayoyin cuta na hanji da kuma daidaita tsarin metabolism ba. Wannan binciken ya cike wannan gibin ta hanyar binciken yadda quercetin ke sake tsara yanayin halittu na ƙwayoyin cuta don hana tarin lipids.Labaran Quercetin 6 - pic2.jpg

Muhimman Abubuwan da aka Gano

  1. Ingantaccen Abinci Mai Gina Jiki:
    Quercetin ƙarin abinci a cikin beraye masu yawan kitse (HFD):

    • Rage nauyin jiki da kitse
    • Rage juriyar insulin da dyslipidemia

  2. Gyaran Gut Microbiota:
    An bayyana jerin 16S rRNA quercetin:

    • An wadata Akkermansia muciniphila yalwa (> ƙaruwa sau 3)
    • An dawo da bambancin ƙwayoyin cuta da HFD ya lalata

  3. Siginar Metabolite ta ƙwayoyin cuta:
    A. muciniphila yana samar da indole-3-lactic acid (ILA), wanda ke samar da:

    • Kunna hanyar demethylation ta m6A da FTO ta shiga tsakani
    • Ingantaccen yanayin CYP8B1 na hanta (maɓallin enzyme don haɗa bile acid)

  4. Tsarin Lipid Mai Matsakaici da Bile Acid:
    Haɗa sinadarin cholic acid (CA) da CYP8B1 ke jagoranta ya kunna ƙwayar adipose Farnesoid X Receptor (FXR), wanda ke haifar da:

    • An danne kuma lipogenesis (SREBP1c↓, FAS↓)
    • Ingantaccen iskar shaka ta lipid (PPARα↑)

Labaran Quercetin 6 - pic3.jpg

Tabbatar da Injini

  • Beraye marasa ƙwayoyin cuta an dasa shi da A. muciniphila maimaita tasirin quercetin na hana kiba.
  • Hukumar ILA rage tarin lipids ta hanyar siginar FTO/m6A/CYP8B1.
  • knockout na FXR ya kawar da fa'idodin rage kitse na quercetin, yana tabbatar da buƙatar hanyoyin rayuwa.

Muhimmanci da Ma'anoni

"Wannan aikin yana tabbatar da cewa an yi quercetin–Gidan Gona–Axis na ILA/CA/FXR a matsayin babban mai kula da metabolism na lipid," in ji marubuciyar da ke bibiyar wannan lamari, Farfesa Xinxia Wang. "Yin niyya ga wannan hanyar hanta da hanji yana ba da sabuwar dabarar magance kiba fiye da hanyoyin gargajiya." Sakamakon ya nuna yadda ake daidaita ƙwayoyin cuta a matsayin hanya mai kyau don haɓaka samfuran halitta.