Nicotinamide Adenine Dinucleotide
β-NAD+ muhimmin coenzyme ne da ake samu a cikin dukkan ƙwayoyin halitta masu rai, yana taka muhimmiyar rawa a cikin metabolism ta hanyar sauƙaƙe canja wurin electrons a cikin halayen redox. Yana da mahimmanci ga samar da makamashi, gyaran DNA, da kuma daidaita hanyoyin ƙwayoyin halitta da suka shafi tsufa. Matakan β-NAD+ a dabi'ance suna raguwa da shekaru, kuma ƙarin abinci na iya taimakawa wajen dawo da ingantaccen aikin ƙwayoyin halitta da haɓaka tsawon rai.
Bayani dalla-dalla: 99%
Samar da makamashi: β-NAD+ yana da mahimmanci ga samar da ATP, haɓaka aikin mitochondrial da haɓaka matakan makamashi gabaɗaya ”Yoshino et al., 2018”
Gyaran DNA: β-NAD+ yana kunna enzymes kamar PARPs, waɗanda ke taimakawa wajen gyara lalacewar DNA, tallafawa lafiyar ƙwayoyin halitta da tsawon rai【Belenky et al., 2007】.
Maganin tsufa da tsawon rai: β-NAD+ yana taka muhimmiyar rawa wajen kunna sirtuins, enzymes da ke da alaƙa da tsawon rai, inganta lafiyar metabolism da kuma rage jinkirin tsufa【Gomes et al., 2013】.
Aikin Fahimta: An nuna cewa ƙarin NAD+ yana tallafawa lafiyar kwakwalwa, inganta ƙwaƙwalwa, da haɓaka aikin fahimi【Vaur et al., 2017】.
Tsarin aiki
β-NAD+ yana aiki a matsayin coenzyme a cikin halayen redox, yana taimakawa wajen canja wurin electrons yayin numfashin tantanin halitta da samar da ATP a cikin mitochondria. Hakanan yana taka muhimmiyar rawa a cikin kunna sirtuin, wanda ke daidaita gyaran DNA, kumburi, da hanyoyin rayuwa da ke da alaƙa da tsufa【Yoshino et al., 2018】. β-NAD+ yana ƙara tallafawa kunna enzymes na PARP, waɗanda ke taimakawa wajen kiyaye kwanciyar hankali na kwayoyin halitta da aikin tantanin halitta【Belenky et al., 2007】.
Nassoshi
Yoshino, J., da sauransu (2018). Matsakaici na NAD+: Ilimin halittu da yuwuwar warkewa na NMN da NR. Metabolism na ƙwayoyin halitta.
Belenky, P., da sauransu (2007). Tsarin metabolism na NAD+ a cikin lafiya da cututtuka. Kwayoyin halitta.
Gomes, AP, da sauransu (2013). Ragewar NAD+ yana haifar da yanayin da ba a iya gani ba wanda ke kawo cikas ga sadarwa tsakanin nukiliya da mitochondria yayin tsufa. Kwayoyin halitta.
Vaur, P., et al. (2017). Tsarin metabolism na NAD+ a matsayin maƙasudin magani ga cututtukan da suka shafi tsufa. Mujallar Binciken Asibiti.